KIF23

kinesin family member 23

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 258/597

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (7.0e-05)
2. Glioma (1.7e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotESPL10.26
PlotKIF110.26
PlotCDCA80.25
PlotWEE10.25
PlotPRC10.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRACGAP10.40
PlotCIT0.33
PlotCIT0.33
PlotPRC10.32
PlotRBM390.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (15 69705687-69706687)

Methylation (1kb upstream TSS) (15 69705584-69706584)

CpG Methylation

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  • Official symbol: KIF23
  • Full name: kinesin family member 23
  • Location:
  • Also known as: MKLP1, KNSL5, MKLP-1
  • Entrez ID: 9493
  • Ensembl ID: ENSG00000137807

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