KLB

klotho beta

Dependent Cell Lines

CRISPR: 3/625 STRONGLY SELECTIVE

RNAi: 3/600 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Liver (3.6e-07)
2. B-cell ALL (1.1e-04)
3. Breast (2.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotIYD0.23
PlotNWD20.22
PlotNR5A20.22
PlotKCNIP40.21
PlotPRPS10.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotWNT8A0.28
PlotRSPH4A0.28
PlotKIAA1324-0.27
PlotSTXBP5L0.26
PlotLYPD30.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: KLB
  • Full name: klotho beta
  • Location:
  • Also known as:
  • Entrez ID: 152831
  • Ensembl ID: ENSG00000134962

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