MAD2L1

mitotic arrest deficient 2 like 1

Dependent Cell Lines

CRISPR: 584/625 COMMON ESSENTIAL

RNAi: 674/708 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Rhabdoid (3.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (1.2e-10)
2. Leukemia (5.1e-09)
3. Solid (9.0e-08)
4. B-cell ALL (1.2e-07)
5. Neuroblastoma (4.6e-06)
6. Peripheral Nervous System (4.6e-06)
7. Mesothelioma (1.4e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRARS0.34
PlotTTK0.33
PlotRPL50.32
PlotLSM60.32
PlotMIS120.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotBUB1B0.42
PlotSUCLG20.37
PlotN4BP20.36
PlotTRIM680.36
PlotTCFL50.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (4 120988013-120989013)

CpG Methylation

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  • Official symbol: MAD2L1
  • Full name: mitotic arrest deficient 2 like 1
  • Location:
  • Also known as: HSMAD2, MAD2
  • Entrez ID: 4085
  • Ensembl ID: ENSG00000164109

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