MCL1

MCL1, BCL2 family apoptosis regulator

Dependent Cell Lines

CRISPR: 362/625 COMMON ESSENTIAL

RNAi: 32/712 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (2.9e-09)
2. Haematopoietic And Lymphoid (4.6e-09)
3. Multiple Myeloma (1.7e-04)
4. Pancreas (2.3e-04)
5. Leukemia (3.3e-04)
6. AML (3.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Multiple Myeloma (7.7e-05)
2. Breast (4.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMARCH50.67
PlotUBE2J20.37
PlotBCL2L20.34
PlotBCL20.30
PlotTHAP30.30

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSLC44A50.41
PlotSLC44A50.41
PlotATG2A0.37
PlotATG2A0.37
PlotVDAC20.35

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: MCL1
  • Full name: MCL1, BCL2 family apoptosis regulator
  • Location:
  • Also known as: Mcl-1, BCL2L3
  • Entrez ID: 4170
  • Ensembl ID: ENSG00000143384

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