MED11

mediator complex subunit 11

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 236/383

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Multiple Myeloma (2.4e-06)
2. Haematopoietic And Lymphoid (3.4e-05)
3. Solid (5.2e-05)

RNAi

Dependency Score (DEMETER2)

1. Pancreas (2.1e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMED90.38
PlotMED300.38
PlotMED10.36
PlotMED180.35
PlotMED80.35

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUTP3-0.66
PlotMED90.47
PlotMED40.45
PlotMED300.43
PlotMED280.40

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: MED11
  • Full name: mediator complex subunit 11
  • Location:
  • Also known as: HSPC296, MGC88387
  • Entrez ID: 400569
  • Ensembl ID: ENSG00000161920

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