MED14

mediator complex subunit 14

Dependent Cell Lines

CRISPR: 567/582 COMMON ESSENTIAL

RNAi: 491/711 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (1.1e-04)
2. Haematopoietic And Lymphoid (1.1e-04)

RNAi

Dependency Score (DEMETER2)

1. Lung Small (1.9e-05)
2. Esophagus (4.0e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotIGBP10.41
PlotTAF10.40
PlotUXT0.36
PlotPOLA10.36
PlotGPKOW0.35

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMED10.49
PlotMED260.41
PlotYRDC-0.40
PlotOR5L2-0.39
PlotSMC1A0.38

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for MED14

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Translocation

Loading table...



  • Official symbol: MED14
  • Full name: mediator complex subunit 14
  • Location:
  • Also known as: CXorf4, EXLM1, CRSP150, RGR1, TRAP170, CRSP2, CSRP
  • Entrez ID: 9282
  • Ensembl ID: ENSG00000180182

Search external sites for MED14