MEN1

menin 1

Dependent Cell Lines

CRISPR: 271/625

RNAi: 6/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (2.8e-11)
2. Solid (6.8e-11)
3. Multiple Myeloma (8.1e-09)
4. DLBCL (5.1e-06)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotKMT2A0.65
PlotDOT1L0.60
PlotPSIP10.54
PlotMLLT100.44
PlotJADE20.41

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCDC960.41
PlotSTIM10.38
PlotOR4D20.35
PlotUTP3-0.34
PlotUTP3-0.34

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (11 64578188-64579188)

Methylation (1kb upstream TSS) (11 64578766-64579766)

Methylation (1kb upstream TSS) (11 64578035-64579035)

Methylation (1kb upstream TSS) (11 64578213-64579213)

CpG Methylation

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  • Official symbol: MEN1
  • Full name: menin 1
  • Location:
  • Also known as:
  • Entrez ID: 4221
  • Ensembl ID: ENSG00000133895

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