MIOS

meiosis regulator for oocyte development

Dependent Cell Lines

CRISPR: 425/625 COMMON ESSENTIAL

RNAi: 4/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (1.7e-11)
2. Solid (4.2e-11)
3. Leukemia (4.7e-06)
4. Lymphoma (3.0e-04)
5. Neuroblastoma (3.2e-04)
6. Peripheral Nervous System (3.2e-04)

RNAi

Dependency Score (DEMETER2)

1. B-cell ALL (4.5e-07)
2. Glioma (1.2e-05)
3. Haematopoietic And Lymphoid (5.0e-05)
4. Leukemia (6.8e-05)
5. Glioblastoma (1.6e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotWDR240.74
PlotWDR590.62
PlotSEH1L0.50
PlotLAMTOR40.36
PlotLAMTOR30.36

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCDC1140.38
PlotSEH1L0.38
PlotWDR240.33
PlotEML60.30
PlotTP53I110.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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  • Official symbol: MIOS
  • Full name: meiosis regulator for oocyte development
  • Location:
  • Also known as: MIO, FLJ20323, Yulink, Sea4
  • Entrez ID: 54468
  • Ensembl ID: ENSG00000164654

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