MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

Dependent Cell Lines

CRISPR: 1/625

RNAi: 5/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCRELD20.26
PlotRABL2B0.24
PlotSYCE30.23
PlotZBED40.22
PlotFAM19A50.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotAGBL30.69
PlotCCR70.68
PlotSGCB0.65
PlotUSP400.62
PlotOCA20.62

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for MLC1

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...



  • Official symbol: MLC1
  • Full name: megalencephalic leukoencephalopathy with subcortical cysts 1
  • Location:
  • Also known as: VL, MLC, KIAA0027, LVM
  • Entrez ID: 23209
  • Ensembl ID: ENSG00000100427

Search external sites for MLC1