MORC3

MORC family CW-type zinc finger 3

Dependent Cell Lines

CRISPR: 0/625

RNAi: 14/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (4.9e-06)
2. Skin (1.3e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (1.4e-05)
2. Solid (2.6e-05)
3. Leukemia (3.5e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSETD40.31
PlotMX20.27
PlotKCNJ60.27
PlotITSN10.26
PlotCBR10.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMLC10.61
PlotUSP400.60
PlotSYT90.60
PlotPCDHGA30.56
PlotAGBL30.55

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (21 37691486-37692486)

CpG Methylation

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  • Official symbol: MORC3
  • Full name: MORC family CW-type zinc finger 3
  • Location:
  • Also known as: KIAA0136, NXP2, ZCW5, ZCWCC3
  • Entrez ID: 23515
  • Ensembl ID: ENSG00000159256

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