MSH6

mutS homolog 6

Dependent Cell Lines

CRISPR: 1/625

RNAi: 1/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Rhabdoid (2.5e-04)
2. Uterus Endometrium (4.6e-04)

RNAi

Dependency Score (DEMETER2)

1. Solid (5.6e-08)
2. Leukemia (1.4e-07)
3. Haematopoietic And Lymphoid (3.6e-07)
4. AML (8.4e-06)
5. B-cell ALL (4.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotM1AP0.33
PlotHAAO0.31
PlotMAEL0.27
PlotFSHR0.26
PlotMECP20.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotWDFY40.37
PlotFER1L60.32
PlotTECPR20.29
PlotAAMDC0.28
PlotWDR410.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (2 48009220-48010220)

Methylation (1kb upstream TSS) (2 48010093-48011093)

CpG Methylation

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  • Official symbol: MSH6
  • Full name: mutS homolog 6
  • Location:
  • Also known as: GTBP
  • Entrez ID: 2956
  • Ensembl ID: ENSG00000116062

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