MTF1

metal regulatory transcription factor 1

Dependent Cell Lines

CRISPR: 55/625

RNAi: 2/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (2.6e-09)
2. Haematopoietic And Lymphoid (3.4e-09)
3. Leukemia (4.2e-09)
4. B-cell ALL (9.6e-05)
5. Skin (4.0e-04)
6. AML (4.9e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCBFB0.25
PlotSLC30A10.25
PlotRPL220.25
PlotTP530.23
PlotTP53BP10.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPRSS450.30
PlotKDM6B0.30
PlotCOMMD90.28
PlotHCG270.27
PlotNR1I3-0.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 38325292-38326292)

CpG Methylation

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  • Official symbol: MTF1
  • Full name: metal regulatory transcription factor 1
  • Location:
  • Also known as:
  • Entrez ID: 4520
  • Ensembl ID: ENSG00000188786

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