MTHFD1

methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Dependent Cell Lines

CRISPR: 101/625

RNAi: 40/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (3.3e-21)
2. Solid (4.2e-20)
3. Leukemia (2.2e-10)
4. Multiple Myeloma (1.1e-09)
5. Central Nervous System (2.1e-05)
6. AML (2.2e-05)
7. Glioma (2.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (3.2e-23)
2. Solid (1.2e-22)
3. Leukemia (1.2e-21)
4. AML (2.8e-10)
5. B-cell ALL (4.4e-08)
6. Multiple Myeloma (4.8e-05)
7. Colorectal (1.3e-04)
8. Colorectal MSI (2.0e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPAICS0.79
PlotATIC0.79
PlotPPAT0.77
PlotGART0.76
PlotPFAS0.74

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotDLST0.37
PlotPAICS0.34
PlotADSL0.34
PlotOGDH0.34
PlotKIF5C0.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (14 64854070-64855070)

CpG Methylation

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  • Official symbol: MTHFD1
  • Full name: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
  • Location:
  • Also known as: MTHFD, MTHFC
  • Entrez ID: 4522
  • Ensembl ID: ENSG00000100714

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