NCOR1

nuclear receptor corepressor 1

Dependent Cell Lines

CRISPR: 27/625

RNAi: 54/711

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (6.5e-05)
2. Skin (7.2e-05)

RNAi

Dependency Score (DEMETER2)

1. TNBC (9.2e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTBL1XR10.33
PlotHDAC30.32
PlotUBB0.29
PlotTRPV20.25
PlotZNF2870.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotH2AFV0.41
PlotRPL230.39
PlotPOPDC30.36
PlotOR52H10.36
PlotRPL110.36

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (17 16118874-16119874)

CpG Methylation

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  • Official symbol: NCOR1
  • Full name: nuclear receptor corepressor 1
  • Location:
  • Also known as: KIAA1047, hCIT529I10, MGC104216, hN-CoR, PPP1R109, N-CoR, TRAC1
  • Entrez ID: 9611
  • Ensembl ID: ENSG00000141027

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