NEDD1

neural precursor cell expressed, developmentally down-regulated 1

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 443/600

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (2.6e-05)
2. Solid (3.9e-05)
3. Neuroblastoma (1.1e-04)
4. Peripheral Nervous System (1.1e-04)
5. Leukemia (3.8e-04)

RNAi

Dependency Score (DEMETER2)

1. Neuroblastoma (2.9e-05)
2. Peripheral Nervous System (2.9e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotKIF110.51
PlotPSMD70.49
PlotCHEK10.47
PlotSNRNP2000.45
PlotSARS0.45

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCKAP50.33
PlotKIF110.31
PlotSNRPF0.31
PlotTUBGCP30.30
PlotTUBGCP20.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (12 97300000-97301000)

Methylation (1kb upstream TSS) (12 97300243-97301243)

CpG Methylation

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  • Official symbol: NEDD1
  • Full name: neural precursor cell expressed, developmentally down-regulated 1
  • Location:
  • Also known as: TUBGCP7, GCP-WD
  • Entrez ID: 121441
  • Ensembl ID: ENSG00000139350

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