NFIC

nuclear factor I C

Dependent Cell Lines

CRISPR: 13/625

RNAi: 2/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (2.4e-13)
2. Leukemia (2.6e-10)
3. Solid (4.3e-08)
4. AML (1.0e-06)
5. ERpos (1.8e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNFIX0.37
PlotJUNB0.26
PlotZFP36L10.24
PlotJUN0.24
PlotAES0.23

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotKRT70.34
PlotAPBA20.33
PlotUTP30.33
PlotUTP30.33
PlotN4BP2L1-0.32

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for NFIC

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Translocation

Loading table...

Methylation (1kb upstream TSS) (19 3358560-3359560)

Methylation (1kb upstream TSS) (19 3365564-3366564)

CpG Methylation

Select context(s) and press load



  • Official symbol: NFIC
  • Full name: nuclear factor I C
  • Location:
  • Also known as: NF-I, CTF5, NFI, CTF
  • Entrez ID: 4782
  • Ensembl ID: ENSG00000141905

Search external sites for NFIC