NGDN

neuroguidin

Dependent Cell Lines

CRISPR: 113/625 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Kidney (3.2e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNBPF100.26
PlotUSP390.26
PlotU2SURP-0.24
PlotCOPS30.22
PlotEFNA30.22

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (14 23937897-23938897)

CpG Methylation

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  • Official symbol: NGDN
  • Full name: neuroguidin
  • Location:
  • Also known as: CANu1, C14orf120, lpd-2, LCP5, DKFZP564O092, NGD
  • Entrez ID: 25983
  • Ensembl ID: ENSG00000129460

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