NR5A1

nuclear receptor subfamily 5 group A member 1

Dependent Cell Lines

CRISPR: 4/625

RNAi: 2/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Lung Small (2.0e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotAK10.24
PlotGAL3ST20.23
PlotWDR5B-0.22
PlotFOXE30.22
PlotSLC25A250.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTRIM670.32
PlotTEKT10.28
PlotIRF2BPL0.28
PlotZP10.27
PlotDEDD0.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (9 127269699-127270699)

CpG Methylation

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  • Official symbol: NR5A1
  • Full name: nuclear receptor subfamily 5 group A member 1
  • Location:
  • Also known as: AD4BP, SF-1, ELP, SF1, FTZF1, FTZ1, hSF-1
  • Entrez ID: 2516
  • Ensembl ID: ENSG00000136931

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