NUP37

nucleoporin 37

Dependent Cell Lines

CRISPR: 92/625

RNAi: 2/600

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Multiple Myeloma (2.6e-07)
2. Haematopoietic And Lymphoid (6.1e-05)
3. Solid (7.0e-05)

RNAi

Dependency Score (DEMETER2)

1. Central Nervous System (1.0e-06)
2. Medulloblastoma (1.1e-04)
3. Glioblastoma (1.7e-04)
4. Kidney (1.7e-04)
5. Med Group 3 (2.4e-04)
6. Neuroblastoma (2.7e-04)
7. Peripheral Nervous System (2.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNUP1330.35
PlotAHCTF10.34
PlotKPNA20.34
PlotCDCA30.33
PlotNDC10.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotWDR530.35
PlotLYPD30.32
PlotWDR380.32
PlotLINC015540.31
PlotARHGEF380.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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  • Official symbol: NUP37
  • Full name: nucleoporin 37
  • Location:
  • Also known as: MGC5585, FLJ22618
  • Entrez ID: 79023
  • Ensembl ID: ENSG00000075188

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