NUP58

nucleoporin 58

Dependent Cell Lines

CRISPR: 220/625

RNAi: 350/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotNKTR0.32
PlotGTF3A0.30
PlotUSPL10.27
PlotZC3H130.27
PlotNUP620.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotNUP540.43
PlotCMTM80.40
PlotMMP280.39
PlotTMEM1070.33
PlotCSF10.33

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (13 25874665-25875665)

CpG Methylation

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  • Official symbol: NUP58
  • Full name: nucleoporin 58
  • Location:
  • Also known as: KIAA0410, NUPL1, NUP45
  • Entrez ID: 9818
  • Ensembl ID: ENSG00000139496

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