NUTF2

nuclear transport factor 2

Dependent Cell Lines

CRISPR: 624/625 COMMON ESSENTIAL

RNAi: 687/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Bone (3.6e-06)
2. Ewing Sarcoma (4.5e-06)
3. Leukemia (5.1e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSNU130.52
PlotPSMA40.48
PlotUBL50.44
PlotPHF5A0.43
PlotFAM25G0.42

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRAN0.62
PlotWISP10.44
PlotEHF0.42
PlotANAPC10.35
PlotPHF5A0.35

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (16 67880016-67881016)

Methylation (1kb upstream TSS) (16 67879634-67880634)

CpG Methylation

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  • Official symbol: NUTF2
  • Full name: nuclear transport factor 2
  • Location:
  • Also known as: PP15, NTF2
  • Entrez ID: 10204
  • Ensembl ID: ENSG00000102898

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