NXT1

nuclear transport factor 2 like export factor 1

Dependent Cell Lines

CRISPR: 219/625 STRONGLY SELECTIVE

RNAi: 164/597

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Rhabdomyosarcoma (2.3e-08)
2. Neuroblastoma (1.2e-06)
3. Peripheral Nervous System (1.2e-06)
4. Haematopoietic And Lymphoid (7.0e-06)
5. Solid (8.2e-06)

RNAi

Dependency Score (DEMETER2)

1. Lung Large (4.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRNF113A0.27
PlotACO20.22
PlotODR4-0.22
PlotUFM1-0.22
PlotSYVN1-0.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotNXF10.36
PlotMCM3AP0.31
PlotAPOC4-0.28
PlotORMDL30.27
PlotPCNA0.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (20 23330372-23331372)

CpG Methylation

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  • Official symbol: NXT1
  • Full name: nuclear transport factor 2 like export factor 1
  • Location:
  • Also known as: P15, MTR2
  • Entrez ID: 29107
  • Ensembl ID: ENSG00000132661

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