OR2V1

olfactory receptor family 2 subfamily V member 1

Dependent Cell Lines

CRISPR: 1/625

RNAi: 2/383

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Multiple Myeloma (6.8e-06)
2. Haematopoietic And Lymphoid (3.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotLCN80.24
PlotF110.24
PlotMIB20.24
PlotRPL27A0.22
PlotZNF6720.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCDC96-0.45
PlotCCDC96-0.45
PlotN4BP2L10.44
PlotN4BP2L10.44
PlotC12orf43-0.42

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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  • Official symbol: OR2V1
  • Full name: olfactory receptor family 2 subfamily V member 1
  • Location:
  • Also known as: OST265, OR2V1P
  • Entrez ID: 26693
  • Ensembl ID: ENSG00000185372

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