OR52H1

olfactory receptor family 52 subfamily H member 1 (gene/pseudogene)

Dependent Cell Lines

CRISPR: 0/789

RNAi: 20/285

Gene Effect

Dependent Cell Line:

A cell line is considered dependent if it has a probability of dependency greater than 0.5.

Probability of Dependency:

Probabilities of dependency are calculated for each gene score in a cell line as the probability that score arises from the distribution of essential gene scores rather than nonessential gene scores. See here for details.

Gene Effect:

Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.

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Enriched Lineages

CRISPR

Gene Effect (CERES)

RNAi

Gene Effect (DEMETER2)

1. ERneg HER2pos (1.0e-04) n=3
2. Melanoma (1.2e-04) n=27
3. Skin (4.9e-04) n=30

Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.

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Expression & CN

Expression

Copy Number log2(relative to ploidy + 1)

Expression:

RNASeq files are aligned with STAR and quantified with RSEM, then TPM-normalized. Reported values are log2(TPM+1).

Copy Number:

The relative copy number pipeline used varies by cell line. For around 1000 lines, Sanger WES data was used, while for around 700 lines, Broad WES data was used. The remaining lines use SNP array data as explained in 10.1038/s41586-019-1186-3. See 10.1101/720243 for details on how CN source is chosen per line. Lines with WES data were processed through GATK using PONs from TCGA without matched normals and transformed by log2(x+1).

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Top Co-dependencies

CRISPR (Avana) Public 20Q3

	Gene	Pearson correlation
Plot	OR51B4	0.18
Plot	CFTR	-0.17
Plot	C19orf38	-0.17
Plot	ASCL3	0.17
Plot	ADGRE5	-0.17

Combined RNAi (Broad, Novartis, Marcotte)

	Gene	Pearson correlation
Plot	MAN1A1	0.74
Plot	NAT1	0.69
Plot	OR56B4	0.68
Plot	OR1J4	0.68
Plot	SMIM20	0.68

Target Tractability

Mutations

# of cell lines

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Description

Search external sites for OR52H1

PubMed ( entries)
GeneCards
GTEx
NCBI

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Expression Public 20Q3

Copy Number (Absolute)

Copy Number Public 20Q3

Mutation Public 20Q3

Show lineage subtypes

Expression Public 20Q3

Copy Number (Absolute)

Copy Number Public 20Q3

Mutation Public 20Q3

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Official symbol: OR52H1
Full name: olfactory receptor family 52 subfamily H member 1 (gene/pseudogene)
Location:
Also known as:
Entrez ID: 390067
Ensembl ID: ENSG00000181616