P2RY6

pyrimidinergic receptor P2Y6

Dependent Cell Lines

CRISPR: 16/625

RNAi: 2/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUCP30.40
PlotPLEKHB10.39
PlotTBX100.39
PlotRELT0.38
PlotOMP0.38

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotOR52H10.40
PlotSMIM200.37
PlotHEXIM20.36
PlotOR1J40.35
PlotVWA5B20.34

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (11 72982186-72983186)

Methylation (1kb upstream TSS) (11 72979938-72980938)

Methylation (1kb upstream TSS) (11 72974549-72975549)

Methylation (1kb upstream TSS) (11 72974596-72975596)

Methylation (1kb upstream TSS) (11 72975280-72976280)

CpG Methylation

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  • Official symbol: P2RY6
  • Full name: pyrimidinergic receptor P2Y6
  • Location:
  • Also known as: P2Y6
  • Entrez ID: 5031
  • Ensembl ID: ENSG00000171631

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