PABPC5

poly(A) binding protein cytoplasmic 5

Dependent Cell Lines

CRISPR: 1/582

RNAi: 0/597

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTBX220.34
PlotNAP1L30.28
PlotPCDH11X0.28
PlotTGIF2LX0.27
PlotRAB9B0.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotFAM19A30.34
PlotC12orf430.33
PlotC12orf430.33
PlotBZW1-0.31
PlotDPH50.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: PABPC5
  • Full name: poly(A) binding protein cytoplasmic 5
  • Location:
  • Also known as: PABP5
  • Entrez ID: 140886
  • Ensembl ID: ENSG00000174740

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