PASD1

PAS domain containing repressor 1

Dependent Cell Lines

CRISPR: 2/582

RNAi: 7/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Kidney (1.1e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotMMEL10.20
PlotBEX30.19
PlotGGT60.19
PlotIL1RAPL10.18
PlotEPM2AIP10.18

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotKBTBD130.32
PlotTP53AIP10.32
PlotCCDC102B0.31
PlotFSCN30.29
PlotLY6D0.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: PASD1
  • Full name: PAS domain containing repressor 1
  • Location:
  • Also known as: CT63
  • Entrez ID: 139135
  • Ensembl ID: ENSG00000166049

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