PDGFRB

platelet derived growth factor receptor beta

Dependent Cell Lines

CRISPR: 9/625 STRONGLY SELECTIVE

RNAi: 0/711

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Glioma (1.7e-14)
2. Glioblastoma (1.6e-12)
3. Central Nervous System (8.1e-10)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPGAM10.24
PlotUBXN4-0.21
PlotNF1-0.21
PlotFOXF10.20
PlotSPRED1-0.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTMEM169-0.34
PlotRSPH4A0.33
PlotMLIP0.29
PlotTMCO30.28
PlotHID10.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: PDGFRB
  • Full name: platelet derived growth factor receptor beta
  • Location:
  • Also known as: CD140b, PDGFR, PDGFR1, JTK12
  • Entrez ID: 5159
  • Ensembl ID: ENSG00000113721

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