PNPT1

polyribonucleotide nucleotidyltransferase 1

Dependent Cell Lines

CRISPR: 597/625 COMMON ESSENTIAL

RNAi: 395/710 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive Squamous (1.3e-04)
2. Upper Aerodigestive (2.0e-04)

RNAi

Dependency Score (DEMETER2)

1. Breast (2.7e-04)
2. Colorectal MSI (4.2e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSUPV3L10.60
PlotMTPAP0.59
PlotHSD17B100.56
PlotLARS20.56
PlotMRPL390.56

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSUPV3L10.57
PlotPTCD30.55
PlotMRPL380.53
PlotTUFM0.51
PlotMRPL400.51

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (2 55921045-55922045)

CpG Methylation

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  • Official symbol: PNPT1
  • Full name: polyribonucleotide nucleotidyltransferase 1
  • Location:
  • Also known as: DFNB70, PNPase, old-35, OLD35
  • Entrez ID: 87178
  • Ensembl ID: ENSG00000138035

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