POLE3

DNA polymerase epsilon 3, accessory subunit

Dependent Cell Lines

CRISPR: 217/625

RNAi: 1/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Kidney (1.6e-08)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (3.2e-12)
2. Skin (1.4e-10)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPOLE40.74
PlotDSCC10.49
PlotCHTF180.38
PlotCHTF80.37
PlotGLRX30.33

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTSPAN320.36
PlotCCDC96-0.36
PlotCCDC96-0.36
PlotNPTN0.35
PlotSYT90.34

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (9 116173029-116174029)

Methylation (1kb upstream TSS) (9 116172955-116173955)

CpG Methylation

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  • Official symbol: POLE3
  • Full name: DNA polymerase epsilon 3, accessory subunit
  • Location:
  • Also known as: CHARAC17, CHRAC17, p17, Ybl1, CHRAC2
  • Entrez ID: 54107
  • Ensembl ID: ENSG00000148229

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