POLR2C

RNA polymerase II subunit C

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 325/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (9.9e-08)
2. Solid (1.7e-07)
3. Leukemia (1.2e-05)
4. AML (1.3e-05)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (9.9e-08)
2. Solid (1.0e-05)
3. Leukemia (1.5e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSNRPB0.47
PlotRAN0.46
PlotPSMD70.44
PlotCDC450.43
PlotSFPQ0.42

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPOLR2G0.40
PlotPOLR2J0.37
PlotRPL23A-0.36
PlotZNHIT10.35
PlotRPAP10.34

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for POLR2C

View details


Choose dataset

Mutation Public 19Q3

Loading table...



  • Official symbol: POLR2C
  • Full name: RNA polymerase II subunit C
  • Location:
  • Also known as: RPB3
  • Entrez ID: 5432
  • Ensembl ID: ENSG00000102978

Search external sites for POLR2C