PPP1CB

protein phosphatase 1 catalytic subunit beta

Dependent Cell Lines

CRISPR: 511/625 COMMON ESSENTIAL

RNAi: 401/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Rhabdoid (3.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (5.0e-11)
2. Solid (3.3e-07)
3. Leukemia (3.7e-07)
4. AML (1.4e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotYBX30.29
PlotMUC10.28
PlotPPP1CA0.28
PlotKDM6B0.28
PlotPPP1R12A0.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPPP1R12A0.64
PlotPALM30.41
PlotNACA0.41
PlotMYO60.41
PlotATRAID0.39

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (2 28973625-28974625)

CpG Methylation

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  • Official symbol: PPP1CB
  • Full name: protein phosphatase 1 catalytic subunit beta
  • Location:
  • Also known as: PP-1B, PP1B, PP1beta
  • Entrez ID: 5500
  • Ensembl ID: ENSG00000213639

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