PPP2R1A

protein phosphatase 2 scaffold subunit Aalpha

Dependent Cell Lines

CRISPR: 587/625 COMMON ESSENTIAL

RNAi: 494/710 COMMON ESSENTIAL

Dependency Score

Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.

Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.

Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.

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Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Multiple Myeloma (7.9e-09)
2. Haematopoietic And Lymphoid (1.3e-08)
3. Solid (2.3e-08)
4. Colorectal (3.8e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (2.2e-11)
2. Leukemia (3.5e-08)
3. Skin (3.9e-07)
4. Solid (6.4e-07)
5. Melanoma (8.7e-07)
6. AML (9.5e-07)

Enriched lineages have p-values < 0.0005 shown in parentheses.

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Expression & CN

TPM (log2)

Copy Number log2(relative to ploidy + 1)

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Top Co-dependencies

CRISPR (Avana) Public 19Q3

	Gene	Pearson correlation
Plot	PPME1	0.30
Plot	PPP2R2A	0.29
Plot	LCMT1	0.26
Plot	PFAS	-0.24
Plot	NAMPT	-0.24

Combined RNAi (Broad, Novartis, Marcotte)

	Gene	Pearson correlation
Plot	NPSR1-AS1	0.28
Plot	ANAPC1	0.28
Plot	PPP2CA	0.27
Plot	OR2W5	-0.25
Plot	FBL	0.24

Target Tractability

Mutations

# of Cell lines

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Description

Search external sites for PPP2R1A

PubMed ( entries)
GeneCards
GTEx
NCBI

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Choose dataset

CRISPR (Avana) Public 19Q3

CRISPR (GeCKO) 19Q1

CRISPR (Sanger)

Combined RNAi (Broad, Novartis, Marcotte)

RNAi (Broad)

RNAi (Novartis)

Expression Public 19Q3

Copy Number (Absolute)

Copy Number Public 19Q3

Mutation Public 19Q3

Fusion 19Q3

Translocation

Methylation (1kb upstream TSS) (19 52692054-52693054)

CpG Methylation

Expression Public 19Q3

Copy Number (Absolute)

Copy Number Public 19Q3

Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (19 52692054-52693054)

CpG Methylation

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Official symbol: PPP2R1A
Full name: protein phosphatase 2 scaffold subunit Aalpha
Location:
Also known as: PP2A-Aalpha, PR65A, PP2AA
Entrez ID: 5518
Ensembl ID: ENSG00000105568