PSAT1

phosphoserine aminotransferase 1

Dependent Cell Lines

CRISPR: 328/625 STRONGLY SELECTIVECOMMON ESSENTIAL

RNAi: 53/668

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Rhabdoid (2.3e-04)
2. Upper Aerodigestive Squamous (3.9e-04)
3. Upper Aerodigestive (4.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Skin (2.6e-05)
2. Melanoma (8.9e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPHGDH0.34
PlotIDO10.27
PlotGAGE12E0.26
PlotSLC22A130.26
PlotUSP490.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotXRRA10.38
PlotMRE110.34
PlotTJAP10.32
PlotOR2H10.31
PlotLINC02072-0.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (9 80910990-80911990)

CpG Methylation

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  • Official symbol: PSAT1
  • Full name: phosphoserine aminotransferase 1
  • Location:
  • Also known as: PSA
  • Entrez ID: 29968
  • Ensembl ID: ENSG00000135069

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