PTPN23

protein tyrosine phosphatase, non-receptor type 23

Dependent Cell Lines

CRISPR: 614/625 COMMON ESSENTIAL

RNAi: 137/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Upper Aerodigestive (1.9e-08)
2. Upper Aerodigestive Squamous (3.3e-08)
3. Neuroblastoma (5.1e-06)
4. Peripheral Nervous System (5.1e-06)
5. Glioma (3.9e-05)
6. Haematopoietic And Lymphoid (8.0e-05)
7. Central Nervous System (8.5e-05)
8. Solid (1.3e-04)
9. Melanoma (2.0e-04)
10. Leukemia (2.8e-04)
11. Glioblastoma (3.4e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotUSP80.59
PlotUBAP10.55
PlotHGS0.43
PlotCLTC0.40
PlotVPS37A0.38

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotN4BP2L1-0.36
PlotN4BP2L1-0.36
PlotMSANTD10.30
PlotUSP80.30
PlotVPS360.29

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (3 47421471-47422471)

CpG Methylation

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  • Official symbol: PTPN23
  • Full name: protein tyrosine phosphatase, non-receptor type 23
  • Location:
  • Also known as: HD-PTP, KIAA1471, DKFZP564F0923
  • Entrez ID: 25930
  • Ensembl ID: ENSG00000076201

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