RAF1

Raf-1 proto-oncogene, serine/threonine kinase

Dependent Cell Lines

CRISPR: 55/625 STRONGLY SELECTIVE

RNAi: 4/671 STRONGLY SELECTIVE

Dependency Score

Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.

Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.

Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).

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Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (4.1e-08)
2. Pancreas (5.3e-06)
3. Leukemia (8.4e-05)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (2.4e-10)
2. Solid (7.7e-10)
3. AML (2.5e-06)
4. Leukemia (9.5e-06)

Enriched lineages have p-values < 0.0005 shown in parentheses.

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Expression & CN

TPM (log2)

Copy Number log2(relative to ploidy + 1)

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Top Co-dependencies

CRISPR (Avana) Public 19Q3

	Gene	Pearson correlation
Plot	SHOC2	0.68
Plot	NRAS	0.36
Plot	KRAS	0.34
Plot	NF1	-0.29
Plot	FURIN	0.28

Combined RNAi (Broad, Novartis, Marcotte)

	Gene	Pearson correlation
Plot	SHOC2	0.43
Plot	SHOC2	0.43
Plot	KRAS	0.31
Plot	KRAS	0.31
Plot	WNT8A	0.29

Target Tractability

Mutations

# of Cell lines

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Description

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PubMed ( entries)
GeneCards
GTEx
NCBI

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Choose dataset

CRISPR (Avana) Public 19Q3

CRISPR (GeCKO) 19Q1

CRISPR (Sanger)

Combined RNAi (Broad, Novartis, Marcotte)

RNAi (Broad)

RNAi (Novartis)

Official symbol: RAF1
Full name: Raf-1 proto-oncogene, serine/threonine kinase
Location:
Also known as: Raf-1, c-Raf, CRAF
Entrez ID: 5894
Ensembl ID: ENSG00000132155

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

Dependent Cell Lines

CRISPR: 55/625 STRONGLY SELECTIVE

RNAi: 4/671 STRONGLY SELECTIVE

Enriched Lineages

CRISPR

RNAi

Expression & CN

Top Co-dependencies

CRISPR (Avana) Public 19Q3

Combined RNAi (Broad, Novartis, Marcotte)

Target Tractability

Mutations

Description

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Expression Public 19Q3

Copy Number (Absolute)

Copy Number Public 19Q3

Mutation Public 19Q3

Fusion 19Q3

Translocation

Methylation (1kb upstream TSS) (3 12705700-12706700)

Methylation (1kb upstream TSS) (3 12705007-12706007)

CpG Methylation

Protein Array (C-Raf(MP05-739))

Protein Array (C-Raf_pS338)

Protein Array (C-Raf(BD610151))

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