RPA1

replication protein A1

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 678/711 STRONGLY SELECTIVECOMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Neuroblastoma (7.1e-05)
2. Peripheral Nervous System (7.1e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPOLE0.42
PlotPAFAH1B10.38
PlotCDK10.36
PlotSNRPF0.36
PlotRUVBL10.36

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPOLR2A0.47
PlotPOLA10.38
PlotRPA20.38
PlotPRPF80.33
PlotVWCE0.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (17 1732264-1733264)

CpG Methylation

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  • Official symbol: RPA1
  • Full name: replication protein A1
  • Location:
  • Also known as: HSSB, RPA70, REPA1, RF-A, RP-A
  • Entrez ID: 6117
  • Ensembl ID: ENSG00000132383

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