RPL13

ribosomal protein L13

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 566/600

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (5.5e-08)
2. Skin (1.2e-04)

RNAi

Dependency Score (DEMETER2)

1. Synovial Sarcoma (1.6e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRPL23A0.41
PlotRPL370.40
PlotRPL230.40
PlotHSPE10.35
PlotRPL40.35

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRPL180.63
PlotOR56B40.60
PlotOR10AG10.59
PlotMYADML20.58
PlotCCDC1540.56

Target Tractability



Mutations

# of Cell lines



Description

Loading...  

Search external sites for RPL13

View details


Choose dataset

Mutation Public 19Q3

Loading table...

Fusion 19Q3

Loading table...

Methylation (1kb upstream TSS) (16 89626064-89627064)

CpG Methylation

Select context(s) and press load



  • Official symbol: RPL13
  • Full name: ribosomal protein L13
  • Location:
  • Also known as: L13, BBC1, D16S444E
  • Entrez ID: 6137
  • Ensembl ID: ENSG00000167526

Search external sites for RPL13