RPL22L1

ribosomal protein L22 like 1

Dependent Cell Lines

CRISPR: 135/625

RNAi: 23/386 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Colorectal MSI (1.7e-05)
2. Uterus Endometrium (6.3e-05)
3. Uterus (1.5e-04)

RNAi

Dependency Score (DEMETER2)

1. Colorectal MSI (2.2e-18)
2. Colorectal (1.2e-06)
3. Prostate (1.3e-06)
4. Uterus (3.9e-04)
5. Uterus Endometrium (3.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotWRN0.28
PlotNDP0.23
PlotHCFC1R10.22
PlotCLDN90.21
PlotCHEK2-0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotCCDC114-0.55
PlotTRIM670.48
PlotWRN0.47
PlotARMH4-0.39
PlotFCRL6-0.36

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (3 170588045-170589045)

CpG Methylation

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  • Official symbol: RPL22L1
  • Full name: ribosomal protein L22 like 1
  • Location:
  • Also known as:
  • Entrez ID: 200916
  • Ensembl ID: ENSG00000163584

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