RPP25L

ribonuclease P/MRP subunit p25 like

Dependent Cell Lines

CRISPR: 172/625 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Central Nervous System (1.2e-14)
2. Glioma (3.3e-12)
3. Rhabdomyosarcoma (2.5e-08)
4. Lung (2.6e-07)
5. Glioblastoma (8.9e-07)
6. Lung NSC (2.9e-06)
7. B-cell ALL (2.8e-04)
8. Lung Adenocarcinoma (3.1e-04)
9. Lymphoma (3.5e-04)
10. Pancreas (4.1e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPOP70.58
PlotNDUFAF5-0.22
PlotNDUFB8-0.22
PlotSSB0.22
PlotNDUFS2-0.22

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (9 34612110-34613110)

CpG Methylation

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  • Official symbol: RPP25L
  • Full name: ribonuclease P/MRP subunit p25 like
  • Location:
  • Also known as: MGC29635, C9orf23, bA296L22.5
  • Entrez ID: 138716
  • Ensembl ID: ENSG00000164967

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