RRM2

ribonucleotide reductase regulatory subunit M2

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 445/708 COMMON ESSENTIAL

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (4.7e-15)
2. Solid (1.0e-14)
3. Leukemia (6.6e-13)
4. AML (7.9e-10)

RNAi

Dependency Score (DEMETER2)

1. Lymphoma (3.2e-06)
2. DLBCL (2.5e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRRM10.56
PlotRAN0.53
PlotPSMD70.50
PlotSNRNP2000.50
PlotRPL370.49

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRRM10.52
PlotACSM60.33
PlotEEF1AKMT1-0.31
PlotEEF1AKMT1-0.31
PlotCHEK10.31

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (2 10261694-10262694)

Methylation (1kb upstream TSS) (2 10261862-10262862)

CpG Methylation

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  • Official symbol: RRM2
  • Full name: ribonucleotide reductase regulatory subunit M2
  • Location:
  • Also known as:
  • Entrez ID: 6241
  • Ensembl ID: ENSG00000171848

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