SARS

seryl-tRNA synthetase

Dependent Cell Lines

CRISPR: 625/625 COMMON ESSENTIAL

RNAi: 203/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Leukemia (5.8e-06)
2. AML (8.9e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotEIF4A30.53
PlotSNRNP2000.51
PlotKIF110.49
PlotPSMD70.48
PlotEIF2S10.48

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotETV30.28
PlotMETAP20.27
PlotGPHA2-0.26
PlotMAFF0.26
PlotSTARD5-0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (1 109755514-109756514)

CpG Methylation

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  • Official symbol: SARS
  • Full name: seryl-tRNA synthetase
  • Location:
  • Also known as: SERS
  • Entrez ID: 6301
  • Ensembl ID: ENSG00000031698

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