SEC24C

SEC24 homolog C, COPII coat complex component

Dependent Cell Lines

CRISPR: 7/625

RNAi: 1/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Med Group 3 (4.7e-04)

RNAi

Dependency Score (DEMETER2)

1. Melanoma (1.0e-04)
2. Skin (3.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSYNPO2L0.23
PlotMYPN0.22
PlotLGI10.21
PlotDNAJC120.20
PlotOR13A10.20

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotIL17D0.29
PlotIL17D0.29
PlotOR2M50.27
PlotUTP30.25
PlotLRRC24-0.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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  • Official symbol: SEC24C
  • Full name: SEC24 homolog C, COPII coat complex component
  • Location:
  • Also known as: KIAA0079
  • Entrez ID: 9632
  • Ensembl ID: ENSG00000176986

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