SERPINA5

serpin family A member 5

Dependent Cell Lines

CRISPR: 5/625

RNAi: 51/710

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTTC7B0.25
PlotNCEH10.25
PlotFAM173B0.23
PlotCENPK0.22
PlotDIO30.22

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotOR1J40.33
PlotSPIRE10.33
PlotXPO70.33
PlotCEP2950.32
PlotALYREF0.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (14 95046705-95047705)

CpG Methylation

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  • Official symbol: SERPINA5
  • Full name: serpin family A member 5
  • Location:
  • Also known as: PAI3, PCI, PLANH3, PROCI
  • Entrez ID: 5104
  • Ensembl ID: ENSG00000188488

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