SETDB1

SET domain bifurcated 1

Dependent Cell Lines

CRISPR: 437/625 COMMON ESSENTIAL

RNAi: 17/559

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. AML (8.9e-06)
2. Kidney (3.0e-05)
3. Leukemia (1.3e-04)
4. Haematopoietic And Lymphoid (1.9e-04)
5. Solid (2.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Haematopoietic And Lymphoid (1.2e-05)
2. Rhabdoid (2.8e-05)
3. Solid (1.5e-04)
4. Multiple Myeloma (2.7e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotATF7IP0.73
PlotTRIM330.27
PlotMPHOSPH80.26
PlotMED13L0.26
PlotCBX10.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMPLKIP0.41
PlotC20orf1730.37
PlotLY6G6F0.37
PlotARMH4-0.37
PlotKDELR20.36

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 150897814-150898814)

Methylation (1kb upstream TSS) (1 150897838-150898838)

CpG Methylation

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  • Official symbol: SETDB1
  • Full name: SET domain bifurcated 1
  • Location:
  • Also known as: KIAA0067, ESET, KMT1E, TDRD21, KG1T
  • Entrez ID: 9869
  • Ensembl ID: ENSG00000143379

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