SLC16A1

solute carrier family 16 member 1

Dependent Cell Lines

CRISPR: 58/625 STRONGLY SELECTIVE

RNAi: 0/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. B-cell ALL (3.8e-05)
2. Solid (3.3e-04)
3. Haematopoietic And Lymphoid (3.5e-04)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotBSG0.24
PlotILK-0.23
PlotENC10.23
PlotXPNPEP1-0.21
PlotGCLC0.21

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMRPL28-0.36
PlotPXDN-0.36
PlotANKFY10.29
PlotUMODL1-AS1-0.29
PlotTMED10P10.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 113498975-113499975)

Methylation (1kb upstream TSS) (1 113498685-113499685)

CpG Methylation

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  • Official symbol: SLC16A1
  • Full name: solute carrier family 16 member 1
  • Location:
  • Also known as: MCT, MCT1
  • Entrez ID: 6566
  • Ensembl ID: ENSG00000155380

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