SLC25A28

solute carrier family 25 member 28

Dependent Cell Lines

CRISPR: 181/625

RNAi: 1/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Leukemia (2.5e-11)
2. Haematopoietic And Lymphoid (4.8e-10)
3. AML (1.6e-09)
4. Solid (2.0e-09)
5. Liver (1.9e-04)

RNAi

Dependency Score (DEMETER2)

1. Breast (4.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotAGK0.36
PlotTIMM220.34
PlotSTOML20.33
PlotPOLE40.30
PlotTIMM290.28

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotUTP3-0.29
PlotTAS1R30.28
PlotFER0.27
PlotPOC50.26
PlotADH40.25

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (10 101380221-101381221)

CpG Methylation

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  • Official symbol: SLC25A28
  • Full name: solute carrier family 25 member 28
  • Location:
  • Also known as: MRS3/4, MRS4L
  • Entrez ID: 81894
  • Ensembl ID: ENSG00000155287

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