SLC25A37

solute carrier family 25 member 37

Dependent Cell Lines

CRISPR: 25/625 STRONGLY SELECTIVE

RNAi: 0/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Haematopoietic And Lymphoid (3.1e-08)
2. Solid (1.5e-07)
3. Rhabdomyosarcoma (1.7e-06)
4. Leukemia (1.5e-05)

RNAi

Dependency Score (DEMETER2)

1. HER2Amp (7.7e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotTIMM220.33
PlotTIMM290.31
PlotMMS190.27
PlotAGK0.27
PlotDOCK70.26

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotC2orf76-0.35
PlotC2orf76-0.35
PlotUTP30.32
PlotUTP30.32
PlotRSPH4A0.30

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (8 23385307-23386307)

CpG Methylation

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  • Official symbol: SLC25A37
  • Full name: solute carrier family 25 member 37
  • Location:
  • Also known as: MFRN1, MSCP, HT015, MFRN
  • Entrez ID: 51312
  • Ensembl ID: ENSG00000147454

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