SLC25A39

solute carrier family 25 member 39

Dependent Cell Lines

CRISPR: 9/625

RNAi: 0/285

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

RNAi

Dependency Score (DEMETER2)

1. Kidney (4.8e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotCNP0.26
PlotGRN0.25
PlotAOC20.24
PlotRAB11FIP40.24
PlotRUNDC3A0.23

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAN1A1-0.71
PlotTHOP1-0.50
PlotTHOP1-0.50
PlotADAM100.50
PlotADAM100.50

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (17 42402238-42403238)

CpG Methylation

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  • Official symbol: SLC25A39
  • Full name: solute carrier family 25 member 39
  • Location:
  • Also known as: CGI-69, FLJ22407
  • Entrez ID: 51629
  • Ensembl ID: ENSG00000013306

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