SLC38A2

solute carrier family 38 member 2

Dependent Cell Lines

CRISPR: 149/625

RNAi: 1/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (1.9e-05)

RNAi

Dependency Score (DEMETER2)

1. AML (6.8e-06)
2. Leukemia (2.9e-05)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotADSS0.32
PlotOGDH0.30
PlotADSL0.29
PlotSLC38A10.29
PlotARRDC3-0.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotRSPH4A-0.30
PlotF10-0.29
PlotF10-0.29
PlotOR2V20.28
PlotSHD0.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (12 46766645-46767645)

CpG Methylation

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  • Official symbol: SLC38A2
  • Full name: solute carrier family 38 member 2
  • Location:
  • Also known as: KIAA1382, SAT2, ATA2, SNAT2
  • Entrez ID: 54407
  • Ensembl ID: ENSG00000134294

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